-- | --

IDSAVERM_3442 TypeCDS
From4266758 nt length855
To4265904 aa length284
GenefolD1 pI6.25
Definitionputative methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase M.W (Da)29667
NotePF02882: Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain AseI frg.E
SignalP v.4.0Non-secretory protein | plot Categorymetabolism of coenzymes & prosthetic groups

Orthologs (if any)

Bacteria*Reciprocally best hit toScoreE-value
coelSCO4824 folD bifunctional protein (methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase)5450.0e+00
sgrSGR_2714 putative methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase4733.0e-171
samSAM23877_4635 Bifunctional protein FolD5440.0e+00
scabSCAB35711 putative methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase5520.0e+00
saceSACE_6651 methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase3772.0e-133
mtubgi|15610492 PROBABLE BIFUNCTIONAL PROTEIN FOLD: METHYLENETETRAHYDROFOLATE DEHYDROGENASE + METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE [Mycobacterium tuberculosis H37Rv]3751.4e-105
cglugi|19551879 COG0190:5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Corynebacterium glutamicum]3872.5e-109
bsubBG11711 folD, yqiA; methylenetetrahydrofolate dehydrogenase / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9]2583.7e-70
ecoligi|16128513 5,10-methylene-tetrahydrofolate dehydrogenase; 5,10-methylene-tetrahydrofolate cyclohydrolase [Escherichia coli K12]2292.1e-61
paerPA1796 [gene=folD] [prot=5,10-methylene-tetrahydrofolate dehydrogenase / cyclohydrolase] [comment=PA1796]2685.4e-73

*coel, Streptomyces coelicolor A3(2); sgr, Streptomyces griseus IFO13350; sam, Streptomyces ambofaciens ATCC 23877; scab, Streptomyces scabies 87.22; sace, Saccharopolyspora erythraea NRRL2338; mtub, Mycobacterium tuberculosis H37Rv; cglu, Corynebacterium glutamicum; bsub, Bacillus subtilis; ecoli, Escherichia coli K-12; paer, Pseudomonas aeruginosa;

Pfam search result



ModelNo.DescriptionPosition (aa)ScoreE-value

THF_DHG_CYH_C1Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain123-282205.13.4e-61

THF_DHG_CYH1Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain5-120120.53.8e-35

BLAST search result (top 10 hits)

ID DescriptionScoreE-value
WP_055625283.1 MULTISPECIES: bifunctional methylenetetrahydrofolate dehydro... 14070.0e+00
WP_115507668.1 bifunctional methylenetetrahydrofolate dehydrogenase/metheny... 14010.0e+00
WP_151785483.1 bifunctional methylenetetrahydrofolate dehydrogenase/metheny... 14000.0e+00
WP_016434727.1 bifunctional methylenetetrahydrofolate dehydrogenase/metheny... 14000.0e+00
WP_033311484.1 bifunctional methylenetetrahydrofolate dehydrogenase/metheny... 13940.0e+00
WP_019066819.1 MULTISPECIES: bifunctional methylenetetrahydrofolate dehydro... 13940.0e+00
WP_232647502.1 bifunctional methylenetetrahydrofolate dehydrogenase/metheny... 13930.0e+00
WP_086602564.1 MULTISPECIES: bifunctional methylenetetrahydrofolate dehydro... 13930.0e+00
WP_200705143.1 bifunctional methylenetetrahydrofolate dehydrogenase/metheny... 13930.0e+00
WP_133043176.1 bifunctional methylenetetrahydrofolate dehydrogenase/metheny... 13930.0e+00

PSORT result

LocalizationCertaintyPSORT said
cytoplasm0.0090 Seems to have no N-terminal signal seq.