| ID | SAVERM_6496
| Type | CDS
|
| From | 7779615
| nt length | 816
|
| To | 7780430
| aa length | 271
|
| Gene | tlyA
| pI | 6.81
|
| Definition | putative cytotoxin/hemolysin
| M.W (Da) | 28311
|
| Note | PF01479: S4 domain, PF01728: FtsJ-like methyltransferase
| AseI frg. | G2
|
| SignalP v.4.0 | Non-secretory protein | plot
| Category | miscellaneous
|
Orthologs (if any)
| Bacteria* | Reciprocally best hit to | Score | E-value
|
| coel | SCO1782 putative membrane protein | 489 | 5.0e-178
|
| sgr | SGR_5713 putative rRNA methylase | 474 | 3.0e-172
|
| sam | SAM23877_1847 16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyA | 479 | 3.0e-174
|
| scab | SCAB71711 putative cytotoxin/hemolysin | 487 | 3.0e-177
|
| sace | SACE_5250 putative cytotoxin/hemolysin | 281 | 3.0e-96
|
| nfar | nfa19960 tlyA cytotoxin/hemolysin | 315 | 3.5e-87
|
| mtub | gi|15608832 CYTOTOXIN|HAEMOLYSIN HOMOLOGUE TLYA [Mycobacterium tuberculosis H37Rv] | 285 | 3.0e-78
|
| cglu | gi|19552628 COG1189:Predicted rRNA methylases [Corynebacterium glutamicum] | 310 | 6.1e-86
|
| bsub | BG10308 yqxC, yqiF; similar to hemolysin | 161 | 3.4e-41
|
*coel, Streptomyces coelicolor A3(2); sgr, Streptomyces griseus IFO13350; sam, Streptomyces ambofaciens ATCC 23877; scab, Streptomyces scabies 87.22; sace, Saccharopolyspora erythraea NRRL2338; nfar, Nocardia farcinica IFM 10152; mtub, Mycobacterium tuberculosis H37Rv; cglu, Corynebacterium glutamicum; bsub, Bacillus subtilis;
Pfam search result
| Model | No. | Description | Position (aa) | Score | E-value
|
| FtsJ | 1 | FtsJ-like methyltransferase | 65-250 | 64.7 | 1e-17
|
| S4 | 1 | S4 domain | 7-49 | 35.4 | 5.8e-09
|
BLAST search result (top 10 hits)
| ID | Description | Score | E-value
|
| WP_095855441.1 | MULTISPECIES: TlyA family RNA methyltransferase [unclassifie...
| 1157 | 8.9e-159 |
| WP_181651794.1 | TlyA family RNA methyltransferase [Streptomyces sp. WAC00263...
| 1156 | 1.2e-158 |
| WP_075027836.1 | MULTISPECIES: TlyA family RNA methyltransferase [Streptomyce...
| 1156 | 1.2e-158 |
| WP_189191459.1 | TlyA family RNA methyltransferase [Streptomyces albiflavesce...
| 1155 | 1.7e-158 |
| WP_153291378.1 | TlyA family RNA methyltransferase [Streptomyces fagopyri] >g...
| 1154 | 2.1e-158 |
| WP_099923436.1 | TlyA family RNA methyltransferase [Streptomyces sp. GbtcB7]
| 1151 | 6.6e-158 |
| WP_168490311.1 | MULTISPECIES: TlyA family RNA methyltransferase [Streptomyce...
| 1151 | 7.3e-158 |
|
| 1151 | 7.6e-158 |
| QIY95014.1 | TlyA family RNA methyltransferase [Streptomyces sp. S1D4-11]
| 1150 | 8.6e-158 |
| WP_067364893.1 | TlyA family RNA methyltransferase [Streptomyces olivochromog...
| 1150 | 8.6e-158 |
PSORT result
| Localization | Certainty | PSORT said
|
| membrane | 0.2275 | Seems to have no N-terminal signal seq.
|