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IDSAVERM_946 TypeCDS
From1205815 nt length1068
To1204748 aa length355
GeneaveBII pI5.89
DefinitiondTDP-glucose 4,6-dehydratase M.W (Da)38670
Noteavermectin gene cluster AseI frg.A
SignalP v.4.0Non-secretory protein | plot Categoryantibiotic production

Orthologs (if any)

Bacteria*Reciprocally best hit toScoreE-value
coelSCO0749 putative dehydratase3905.0e-137
sgrSGR_638 "putative NDP-glucose-4,6-dehydratase"3921.0e-137
samSAM23877_7105 putative dTDP-glucose 4,6-dehydratase4853.0e-174
scabSCAB84041 putative dTDP-glucose 4,6-dehydratase4059.0e-143
saceSACE_6480 dTDP-glucose 4,6-dehydratase4746.0e-170
nfarnfa2100 rfbB dTDP-glucose-4,6-dehydratase2901.0e-79
mtubgi|15610600 dTDP-GLUCOSE 4,6-DEHYDRATASE RMLB [Mycobacterium tuberculosis H37Rv]2731.7e-74
cglugi|19551583 COG1088:dTDP-D-glucose 4,6-dehydratase [Corynebacterium glutamicum]2744.9e-75
bsubBG10618 spsJ, ipa-72d; spore coat polysaccharide biosynthesis protein spsJ [EC:4.2.1.46]3082.9e-85
ecoligi|49176411 dTDP-glucose 4,6-dehydratase [Escherichia coli K12]2915.9e-80
paerPA5161 [gene=rmlB] [prot=dTDP-D-glucose 4,6-dehydratase] [comment=PA5161]2783.8e-76

*coel, Streptomyces coelicolor A3(2); sgr, Streptomyces griseus IFO13350; sam, Streptomyces ambofaciens ATCC 23877; scab, Streptomyces scabies 87.22; sace, Saccharopolyspora erythraea NRRL2338; nfar, Nocardia farcinica IFM 10152; mtub, Mycobacterium tuberculosis H37Rv; cglu, Corynebacterium glutamicum; bsub, Bacillus subtilis; ecoli, Escherichia coli K-12; paer, Pseudomonas aeruginosa;

Pfam search result



ModelNo.DescriptionPosition (aa)ScoreE-value

GDP_Man_Dehyd1GDP-mannose 4,6 dehydratase2-302263.23.4e-78

Epimerase1NAD dependent epimerase/dehydratase family1-239216.53.5e-64

3Beta_HSD13-beta hydroxysteroid dehydrogenase/isomerase family2-21773.71.1e-20

Polysacc_synt_21Polysaccharide biosynthesis protein2-26066.12.6e-18

NAD_binding_41Male sterility protein2-17956.12.7e-15

RmlD_sub_bind1RmlD substrate binding domain35-30455.15.5e-15

NAD_binding_101NAD(P)H-binding3-16031.21.7e-07

BLAST search result (top 10 hits)

ID DescriptionScoreE-value
WP_040255774.1 dTDP-glucose 4,6-dehydratase [Streptomyces albus] >gb 13011.6e-178
WP_089948128.1 dTDP-glucose 4,6-dehydratase [Lentzea xinjiangensis] >emb 13002.5e-178
NUT93316.1 dTDP-glucose 4,6-dehydratase [Saccharothrix sp.] 12986.6e-178
NKI45253.1 dTDP-glucose 4,6-dehydratase [Streptomyces physcomitrii] 12976.8e-178
WP_146356553.1 dTDP-glucose 4,6-dehydratase [Lentzea tibetensis] >lcl 12961.2e-177
WP_073488102.1 dTDP-glucose 4,6-dehydratase [Streptoalloteichus hindustanus... 12925.5e-177
KUL50528.1 dTDP-glucose 4,6-dehydratase [Streptomyces violaceusniger] 12915.5e-177
WP_112275902.1 dTDP-glucose 4,6-dehydratase [Lentzea terrae] 12916.3e-177
WP_214516964.1 dTDP-glucose 4,6-dehydratase [Streptomyces violaceusniger] 12916.7e-177
WP_121225390.1 dTDP-glucose 4,6-dehydratase [Saccharothrix variisporea] >gb... 12901.1e-176

PSORT result

LocalizationCertaintyPSORT said
cytoplasm0.1997 Seems to have no N-terminal signal seq.